Does Ajax have significant accessibility or browser compatibility limitations?

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Does Ajax have significant accessibility or browser compatibility limitations? Do Ajax applications break the back button? Is Ajax compatible with REST? Are there security considerations with Ajax development? Can Ajax applications be made to work for users who have JavaScript turned off?

The answer to all of these questions is “maybe”. Many developers are already working on ways to address these concerns. We think there's more work to be done to determine all the limitations of Ajax, and we expect the Ajax development community to uncover more issues like these along the way.
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