Microbiology Interview Questions And Answers
Microbiology Interview Questions and Answers will guide us now that Microbiology is the study of microorganisms, which are unicellular or cell-cluster microscopic organisms. This includes eukaryotes such as fungi and protists, and prokaryotes. Viruses, though not strictly classed as living organisms, are also studied. So learn more about Microbiology with the help of this Microbiology Interview Questions with Answers guide
1 ► All Enterobacteriaceae share all of the following characteristics EXCEPT?
2 ► What is the O antigen of Enterobacteriaceae?
3 ► Which of the following statements about the 23-valent pneumococcal vaccine is not correct?
4 ► Which of the following statements about Group B a streptococcus (Streptococcus agalactiae) is not correct?
5 ► A 12 year old boy presents with acute onset of sore throat, fever to 38.9 degrees C and painful anterior cervical lymphadenopathy. On exam the pharynx is red and swollen and the tonsils are covered with yellow-white exudates. The child also has halitosis. Which of the following non-suppurative complications are of concern?
6 ► All of the following statements about the M-protein of Group A- Streptococci are correct EXCEPT?
7 ► Which of the following extracellular enzymes produced by Group A-streptococci is called “spreading factor”, an enzyme important in skin and soft tissue infection?
8 ► The diagnosis of septicemia should be considered in patients who are at increased risk of blood stream infection (often secondary to local disease, such as urinary tract infection or pneumonia). All of the following are factors predisposing patients to septicemia except?
9 ► Physical findings and other factors that should suggest the presence of septicemia in a particular patient are all of the following except?
10 ► It is extremely difficult to eradicate staphylococcal infection in the presence of a foreign body. Thus, infected artificial joints and infected intravenous lines often must be removed in conjunction with optimal intravenous anti-staphylococcal therapy with oxacillin or nafcillin (sometimes in combination with rifampin) in order to eradicate such staphylococcal infections (and these attempts are not always successful). Staphylococcal infection of bone may persist for many years despite what should be optimal antimicrobial therapy. The most likely reason for this tenacity of staphylococcal osteomyelitis is:?
11 ► A 42 year old woman who was complaining of shaking chills and fever went to the Salt Lake City Homeless clinic. She had enlarged lymph nodes in the right axilla. Upstream from the enlarged nodes was an ulcer on the top of the patients right hand. When carefully questioned, the patient said she remembered being bitten there by an insect resembling a horsefly, but with yellow stripes on its abdomen; Its what we used to call a deerfly, she added laconically. The patient denied any contact with rats or fleas. The patients disease was most likely to be:?
12 ► Which of the following diseases are not transmitted by ticks?
13 ► A 20 year old patient comes to the homeless clinic with a skin abscess on the right arm. A swab from the intact skin overlying this abscess grows coagulase negative staphylococci. An aspirate obtained sterilely with a needle and syringe grows Staphylococcus aureus. About these 2 organisms in this patient you can say?
14 ► A person who has a normal healthy immune system acquires a new strain of E. coli that now lives in his gastrointestinal tract. This individual is not ill. A second person with an acute leukemia and no white blood cells acquires the same organism, develops diarrhea followed by hypotension, bacteremia, sepsis, and death. This organism is?
15 ► A 25 year old woman has a 4 year old son who is now recovering from Group A strep pharyngitis. Out of curiosity, the pediatrician does a throat culture on the mother which is positive for Group A strep even though she doesnt have a sore throat. The pediatrician also does an ASO titer and anti DNAse B assay on her both of which are negative. At this point we would say that she?
16 ► Characteristics of a bacterial capsule include?
17 ► As a budding basic scientist you work in a research laboratory and discover a chemical that removes the cell wall from bacteria but leaves the organism undamaged otherwise. Things that the bacteria will lose because of this include?
18 ► Under the electron microscope you keep at home next to your MP3 player you look at a single bacterium living in your mouth. You see a single polar flagellum stretching off from one end looking very much like a tail. A characteristic of this organism should be?
19 ► On the same day the clinical laboratory identifies two strains of the same bacterial species. One of these strains has pili on the surface; the other does not. In terms of the clinical status of the two patients it is likely that?
20 ► Infections caused by anaerobes are?
21 ► The laboratory reports that both blood cultures that are drawn from a 15 year old girl are growing Bacteroides fragilis. She was admitted to the hospital because of acute abdominal pain. You should be concerned that?
22 ► Anaerobic infections are?
23 ► Specific organisms that are considered strict anaerobes include?
24 ► The single most important characteristic of diarrhea caused by Vibrio cholera is?
25 ► A 15 year old boy comes in to clinic with pain in his right ear. He is on his school swim team and spends about 2 hours per day in the pool. Along with the pain in his ear, he has watery drainage coming from the ear canal. On exam his vital signs are normal, and he appears healthy, but his left external ear looks quite red and there is copious watery, slightly green drainage coming from the ear. The organism mostly likely causing this is?
26 ► Helicobacter pylori?
27 ► Nonfermentative gram negative bacilli are?
28 ► The normal habitats of nonfermentative bacteria include the following except?
29 ► A 45 year old woman is admitted to the hospital with acute chest pain. On the second hospital day it is clear that she has had a myocardial infarction. Unfortunately, on the same day she develops acute diarrhea. A stool culture grows Salmonella. This infection is?
30 ► A common type of nosocomial infection is?
31 ► You receive a urine culture report from the laboratory on a 45 year old patient who is a quadriplegic with an indwelling urinary tract catheter. The urine culture is growing >100,000 oxidase positive gram negative bacilli. The most likely organism is?
32 ► An important means of preventing hospital acquired infections is?
33 ► Each of the following statements concerning Q fever is correct EXCEPT?
34 ► Each of the following statements concerning epidemic typhus is correct EXCEPT?
35 ► Which of the following statements is true concerning Q fever?
36 ► Which of the following is true regarding Rickettsia rickettsii?
37 ► Which of the following is not transmitted by ticks?
38 ► Which of the following statements concerning Bartonella henselae is correct?
39 ► The lesions of bacillary angiomatosis in AIDS patients are very similar to the hemangiomatous nodules caused by?
40 ► Which of the following is transmitted by lice?
41 ► Which of the following is the metabolically active form of Chlamydia trachomatis?
42 ► Which of the following pathogens is unlikely to be a cause of nongonococcal urethritis?
43 ► Which of the following statements concerning Chlamydia trachomatis infections is NOT correct?
44 ► A 24-year-old pigeon fancier presents with fever to 40 degrees C, severe, diffuse headache, malaise, dry hacking cough and muscle aches. Lung exam reveals bilateral crackles and there is hepatosplenomegaly. The most likely pathogen causing this mans infection is:?
45 ► Which of the following statements regarding mycoplasmas is NOT correct?
46 ► Which of the following is the most common clinical syndrome associated with Mycoplasma pneumoniae?
47 ► Which of the following pathogens causes invasive joint disease in immuno-compromised hosts?
48 ► Which of the following are characteristics that are shared by Mycoplasma hominis and Ureaplasma urealyticum?
49 ► A 4-year-old child comes to the emergency room with a sore throat, difficulty swallowing, and difficulty breathing. On exam there is obvious difficulty each time the child tries to take in a breath with sounds suggesting obstruction. A lateral neck x-ray shows a swollen epiglottis. The organism most likely to cause this syndrome is?
50 ► The major virulence factor of Haemophilus influenzae type b is?
51 ► Important in the laboratory detection of Haemophilus influenzae is that it is?
52 ► A common characteristic of Capnocytophaga, Moraxella, and Eikenella is that they?
53 ► A common characteristic of Legionella species is that they?
54 ► Most humans become infected with legionella by?
55 ► Legionella infection is more common in patients who?
56 ► A 30-year-old patient comes to clinic complaining of a three-week history of cough. He started with a runny nose, fever and sneezing for a few days followed by a dramatic cough that keeps him up at night. He complains of episodes of coughing where he will have fits of coughing with 10-15 coughs during one exhalation to the point that he is afraid that he will never be able to take in a breath. These coughing episodes are so severe that his ribs are extremely sore. An organism you should consider would be?
57 ► An important characteristic of mycobacteria is that they are?
58 ► You would expect the time course of a typical patient with reactivation tuberculosis before they reach a point requiring hospitalization to take?
59 ► Symptoms of reactivation tuberculosis include?
60 ► A 30 year old patient with advanced HIV infection (AIDS) is admitted to the hospital with a high fever. Blood cultures are performed and you receive a report from the laboratory that they are growing a mycobacteria. The one that is most likely is?
61 ► An important characteristic of all fungal infections is that?
62 ► Some fungi have two different morphological forms, yeast and molds. If they do, it is likely that?
63 ► A 30 year old patient with advanced HIV infection comes into clinic complaining that food is sticking in the back of his throat and in his chest when he tries to swallow. You look in his mouth and see patches of whitish material on the surface that can easily be removed and leaves a red base. The organism most likely to cause this is?
64 ► The infection most often associated with Cryptococcus neoformans is?
65 ► The usual initiating event when infection occurs with a fungus is for?
66 ► A 20 year old college student is part of an archeological team traveling to northeastern Arizona to help excavate Indian ruins. One month after returning she develops a flu-like illness with cough, myalgias, and low grade fever. A chest x-ray shows a small localized infiltrate in the right mid lung field. An organism to consider would be?
67 ► A 22 year old diabetic with poor control of blood glucoses comes into clinic with a 2 month history of nasal congestion and low grade fever. Over the past 3 days he has also had a painful right eye-it hurts to look from side to side. In addition he feels that his vision is impaired now in that eye. On exam his right eye appears red and swollen and seems to be pushed forward. His nasal mucosa on that side appears dark and almost necrotic. You should be worried about?
68 ► The most likely infection to occur following exposure to Sporothrix is?
69 ► Each of the following parasites pass through the human lung at some time during their life cycle but only one establishes a home where it divides and causes a chronic disease state. Which one lives in the lung as a definitive host?
70 ► Each of the following is true regarding Pneumocystis carinii. Which statement is false?
71 ► A 44-year-old native Nigerian who has lived in the USA for 10 years returned to visit his family in Africa and now presents with a history of shaking chills, followed by high fever and then profuse sweating. He states that this is the most severe case of malaria he has ever had. His blood smear shows malaria organisms consistent with Plasmodium falciparum. Which of the following statements is false regarding P. falciparum?
72 ► This July a group of 30 volunteers went to Kenya to help build a school and all of them took prophylaxis to prevent malaria. They claim that they took the medication as prescribed 2 weeks before, during their stay, and for 4 weeks after returning home. In October, one person developed malaria and by April of this year, 9 of the 30 volunteers had been treated for malaria. Which of the following is the least likely explanation for this apparent failure of prevention?
73 ► Each of the following statements (except one) is true regarding malaria. Which one is false?
74 ► A 42-year old patient from Ecuador is admitted with fever, right upper abdominal pain and is found to have a cystic mass of the liver. You suspect an amebic abscess and order stool exams that are reported as positive for E. histolytica and an ameba serology is positive at 1:256. Which statement is false regarding ameba?
75 ► A 30-year old patient is evaluated for chronic diarrhea that has gone on for 4 months with a 20-pound weight loss. By history you find that he has had sex with men for 12 years. You are concerned about the possibility of HIV and his test is positive with a low CD4 count that makes you think of immunodeficiency. You order a test for Cryptosporidium in his stool. Which of the following statements is false regarding Cryptosporidium?
76 ► You see a 20-year old female for complaints of vaginal itching, discharge, pain with intercourse and discomfort with urination. She has had 3 different sexual partners over the past 2 years. As part of your workup, you do a wet mount of vaginal secretions and see a flagellated organism about the size of a white blood cell with twitching motility that makes you think of Trichomonas vaginalis. Which statement is false regarding Trichomonas?
77 ► A 22-year old college student is seen because he has had severe chronic diarrhea and a stool for O&P is positive for Giardia lamblia. He has lost 50 pounds in weight and has been treated for Giardia on 6 occasions only to have it reoccur. You are concerned that he has an immunodeficiency and lab results demonstrate a very low IgA level. Which of the following statements would be false regarding Giardia?
78 ► This year there have been 7 travelers to eastern Africa that have contracted Trypanosoma brucei rhodesiense. They have all presented in the early stage of the disease with a chancre of the skin associated with cellulitis (red hot swelling) around the chancre. Which of the following is false regarding Trypanosoma brucei?
79 ► Blood banks in Southern California and Texas have done studies to evaluate how often blood containing Trypansoma cruzi is found in their blood donor pool. They have found that the incidence varies between 1:8,000 and 1:40,000 donors. If you were making up a list of questions to ask blood donors, which of the following questions would be least helpful in screening to exclude this organism from persons that have grown up in an endemic area?
80 ► This year a report from India indicates that a single dose of Amphotericin B can result in the cure of Leishmania donovani rather than prolonged treatment by fairly toxic medication. If confirmed this will be a major advance in the treatment of Kala-azar. Which of the following statements is false regarding systemic Leishmaniasis?
81 ► You have just examined a patient from Brazil who has a chronic ulcer of his ear that has been present for 6 months. You are concerned that he has Leishmaniasis and want to differentiate L. mexicana from L. braziliensis. Which of the following statements about these 2 organisms is false?
82 ► Several years ago there was an outbreak of Trichinosis among a group of Vietnam immigrants in New York that had made their own pork sausage. About 30 people who ate the sausage all become ill. Which of the following statements is false about Trichinella spiralis?
83 ► You see a young child for evaluation of fever, abdominal pain, enlarged liver and eosinophilia. You suspect toxocariasis from Toxacara canis or cati. Which of the following statements is false about Toxocara?
84 ► A 4th year medical student from the UofU traveled to Northern Ghana during an international rotation to Accra. He was fortunate enough to see a patient with Dracunculus medinensis in which they were extracting a worm from his leg onto a pencil. This parasite is being eradicated from the world. Which of the following is least likely to help rid the world of Dracunculus medinensis?
85 ► A 74-year old World War II Veteran who was a prisoner of war in the Philippines is admitted to the VAH with a Group A-Streptococcal cellulitis resulting from massive swelling of both lower legs from elephantiasis. Which of the following is false regarding elephantiasis caused by Wuchereria bancrofti?
86 ► An ophthalmologist from Cameroon, Africa describes the microfilaria seen in the eye of patients with Onchocerciasis. He states that he treats only after finding 30+ microfilaria because of the toxicity of Diethyl-Carbamazine that was used for treatment. Now with a less toxic agent, (Ivermectin) a major attempt is being made to eradicate Onchocerca volvulus. Which statement is false regarding Onchocerca volvulus?
87 ► Itching around the rectum is commonly caused by the pinworm, Enterobius vermicularis. Which of the following is false regarding pinworms?
88 ► Trichuris trichiura or whipworm is a frequent parasite found in humans. Which of the following is false for Trichuris trichiura?
89 ► In the 1920s, the Rockefeller Foundation funded a physician to go throughout the Pacific Islands to decrease the incidence of hookworm. Each of the following but one would help decrease the incidence of this disease. Which one would not make any change in incidence of Ancylostoma duodenale or Necator americanus?
90 ► An elderly Tongan male was diagnosed with multiple myeloma (a form of cancer) and has been treated with chemotherapy agents for two months. He was then admitted to the hospital with new-onset asthma symptoms that became worse when he was treated with steroids. Many small larvae were found in his sputum and he was found to have a hyper-infection with Strongyloides stercoralis. Which statement is false regarding Strongyloides?
91 ► A physician calls from an outlying hospital to report that his patient has passed a large, white, round worm with pointed ends that is about 8 inches long. He is concerned this could be Echinococcus but the only parasite that matches this description is Ascaris lumbricoides. Which of the following is false regarding Ascaris lumbricoides?
92 ► Humans are the definitive host for Diphyllobothrium latum or the fish tapeworm which competes for Vitamin B12 with its human host. Vitamin B12 deficiency can result in an anemia with production of very large red blood cells, called macrocytic anemia. All of the following would prevent the spread of this disease but one. Which one would not be a method of prevention?
93 ► Taenia saginata and Taenia solium are similar in many ways, but Taenia solium is more dangerous. Which of the following makes T. solium more dangerous?
94 ► A 22-year old Tibetan female is found to have a large multiloculated cyst of the pelvis that is removed and found to be due to Echinococcus granulosus. This is most unusual since most cysts occur in the liver or lung. Which of the following is false regarding Echinococcus granulosus?
95 ► A student returns from a student teaching assignment in Zimbabwe. On the way home she swam in Lake Malawi. She is found to have schistosomiasis. Four of the following answers are good advice on how to prevent schistosomiasis. Which one is bad advice?
96 ► A Chinese male has had right upper quadrant pain for the past 10 years. Workup for gallbladder disease with an ultrasound shows small linear organisms. O&P exam reveals the ovoid, flask shaped egg of Clonorchis sinensis. Which of the following statements is false regarding Clonorchis sinensis?
97 ► The major groups of arthropod-borne viruses include?
98 ► The major pathological features in Yellow Fever include?
99 ► The pathogenesis of dengue hemorrhagic shock syndrome is distinguished from that of uncomplicated dengue by?
100 ► Rabies reaches the central nervous system by?
101 ► Creutzfeldt-Jakob disease is caused by?
102 ► Rabies virus produces infection of?
103 ► The most frequent cause of viral meningitis in the United States is?
104 ► Common symptoms of hepatitis include?
105 ► Hepatitis A can be transmitted by?
106 ► A 30 year old patient comes in with symptoms of hepatitis. The following serological results are obtained: Hepatitis A IgM antibody negative, Hepatitis A IgG antibody positive, Hepatitis B surface antigen positive, Hepatitis B surface antibody negative, Hepatitis C antibody negative. This set of results suggests that the patient has acute?
107 ► A major characteristic of hepatitis C is?
108 ► HIV is the same as?
109 ► The likelihood of HIV being transmitted from a pregnant woman to her infant in the absence of antiretroviral therapy is about?
110 ► One of the characteristics of HIV infection is that?
111 ► Serologic conversion to a positive test for HIV infection occurs?
112 ► One of the key differences between amantidine/rimantidine and the newer neuraminidase inhibitor influenza virus drugs is?
113 ► Which of the following best characterizes antiviral chemotherapy in comparison to bacterial chemotherapy?
114 ► HIV reverse transcriptase, a critical target in modern antiretroviral chemotherapy, performs which critical function for the virus?
115 ► Foscarnet interacts with which of the following viral enzymes?
116 ► Enteroviruses are most closely related to which of the following viruses?
117 ► The following statements are clearly true about enteroviruses EXCEPT?
118 ► All of the following are syndromes associated with enteroviruses EXCEPT?
119 ► Antiviral drugs currently on the market, including acyclovir and pencyclovir are active against enteroviruses?
120 ► All of the following are true statements regarding viruses EXCEPT?
121 ► A cytolytic virus would be expected to cause cytopathic effect in cell culture?
122 ► Influenza virus hemagglutinins play a significant role in which of the following phases of viral replication?
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