Bio Chemistry Interview Question:

What are the main theoretical models that try to explain the formation of the enzyme-substrate complex?

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There are two main models that explain the formation of the enzyme-substrate complex the lock and key model and the induced fit model.

In the lock and key model, the enzyme has a region with specific spatial conformation for the binding of the substrate. In the induced fit model, the binding of the substrate induces a change in the spatial configuration of the enzyme for the substrate to fit.

Enzyme Activity: lock and key model induced fit model
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