1. Explain Do you know how the dose for children is being estimated based on preclinical data?
There are a number of ways of estimating children's doses from preclinical (adult) data - often depends on the therapeutic index of the drug in question (the wider the therapeutic window the less accurate the child's dose needs to be). Sometimes straight weight-basis i.e. 7kg child gets 1/10 dose of 70kg adult.
More accurate (so they say) is a dose based on body surface area (child's surface area is greater in proportion to its body weight than an adult is). There are normograms to calculate surface area from weight and height of child.
All of these may be wrong if clearance of drug in child is significantly different from adult e.g. different metabolism or different route of clearance.
4. Explain DOC for cisplatin induced vomitting:
metaclopramide
domperidone
ondansetron
prochlorperazine?
ondansetron
Inhibiting DNA function
6. Indicate the irreversible alfa receptor antagonist:
Tolazoline
Labetalol
Prazosin
Phenoxybenzamine
Phenoxybenzamine
9. Explain Hypnotic drugs are used to treat:
Psychosis
Sleep disorders
Narcolepsy
Parkinsonian disorders
Sleep disorders
Nadolol
12. Explain Oral contraception failure can occur with A/E:
ampicillin
phenytoin
rifampicin
mebendazole
mebendazole
Decrease the duration of REM sleep
16. Explain indirect-acting adrenoreceptor blocking drug:
Tolazoline
Reserpine
Carvedilol
Prazosin
Reserpine
10-15mg/kg/dose
Serum IgE levels will increase and remain until the parasite is washed out from the body.
