To do this we need to use the IEventBindingService and IComponentChangeService of the IDesignerHost of the form.
To override a base class method using the Visual Basic Code Editor
Open the form that you want to use in the Code Editor.
From the Class Name drop-down list at the top of the Code Editor, choose (Overrides).
A list of the methods is added to the Event list.
From the Method Name list at the top of the Code Editor, choose the method for which you want to create an event handler.
I think we cant change the GUI of new version
No idea if you have then share plz
Following are the steps to make single instance application
1.For a Vb.NET project selected in Solution Explorer, click
Properties on the Project menu.
2.Now Click Application tab.
3.Select the Make single instance application check box.