What are the advantages and disadvantages of transgenic animals for neuroscientific studies?

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the advantages are
► in medical research, transgenic animals are used to
identify the functions of specific factors in complex
homeostatic systems through over- or under-expression of a
modified gene (the inserted transgene);
► in toxicology: as responsive test animals (detection of
toxicants);
► in mammalian developmental genetics;
► in molecular biology, the analysis of the regulation of
gene expression makes use of the evaluation of a specific
genetic change at the level of the whole animal;
► in the pharmaceutical industry, targeted production of
pharmaceutical proteins, drug production and product
efficacy testing;
► in biotechnology: as producers of specific proteins;
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