Of which substance are microtubules made? In which structures and cellular processes do microtubules participate?

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Microtubules are made of consecutive dimers of the protein tubulin (each dimer has an alpha and a beta tubulin associated). Microtubules participate in cell division, they are constituents of cilia and flagella and they also form the centrioles.

Cytoskeleton and Cell Movement - Image Diversity: microtubules tubulin
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